2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-132098
    Bis-propargyl-PEG10 1351373-48-2
    Bis-propargyl-PEG10 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-propargyl-PEG10 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG10
  • HY-140432
    Boc-Aminooxy-PEG3-azide 1235514-15-4
    Boc-Aminooxy-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-Aminooxy-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-Aminooxy-PEG3-azide
  • HY-141346
    S-acetyl-PEG3-Boc 1818294-27-7
    S-acetyl-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    S-acetyl-PEG3-Boc
  • HY-141289
    N-(Propanoic acid)-N-bis(m-PEG12)
    N-(Propanoic acid)-N-bis(m-PEG12) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Propanoic acid)-N-bis(m-PEG12)
  • HY-140323
    Tetraethyl heptane-1,7-diylbis(phosphonate) 5943-17-9
    Tetraethyl heptane-1,7-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tetraethyl heptane-1,7-diylbis(phosphonate)
  • HY-W1048572H
    N3-PEG10000-NH2
    N3-PEG10000-NH2 (Azide-PEG10000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG10000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester.
    N3-PEG10000-NH2
  • HY-140927
    Azido-C3-UV-biotin
    Azido-C3-UV-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-C3-UV-biotin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Azido-C3-UV-biotin
  • HY-134694
    Bromo-PEG2-NH2 hydrobromide 3026677-03-9
    Bromo-PEG2-NH2 hydrobromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-NH2 hydrobromide
  • HY-132034
    Benzyl-PEG6-t-butyl ester 2148296-00-6
    Benzyl-PEG6-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG6-t-butyl ester
  • HY-141322
    PEG4-bis(phosphonic acid diethyl ester) 106338-06-1
    PEG4-bis(phosphonic acid diethyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG4-bis(phosphonic acid diethyl ester)
  • HY-130563
    Propargyl-PEG3-CH2COOH 1694731-93-5 98.0%
    Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-CH2COOH
  • HY-141004
    3,4-Dibromo-Mal-PEG2-amine 1807534-86-6
    3,4-Dibromo-Mal-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    3,4-Dibromo-Mal-PEG2-amine
  • HY-178831
    Azacyclohexane-C-piperazine-C(OCH3)2
    Azacyclohexane-C-piperazine-C(OCH3)2 is a PROTAC linker that can be used to synthesize PROTAC LRRK2 Degrader-4 (HY-178796). PROTAC LRRK2 Degrader-4 is a potent LRRK2 PROTAC degrader with anti-neuroinflammatory activity.
    Azacyclohexane-C-piperazine-C(OCH3)2
  • HY-138323
    Benzyl-PEG36-alcohol
    Benzyl-PEG36-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG36-alcohol
  • HY-123609
    Pyrene-amido-PEG4-azide 1817735-36-6
    Pyrene-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Pyrene-amido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Pyrene-amido-PEG4-azide
  • HY-138333
    Azido-PEG7-PFP ester
    Azido-PEG7-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-PFP ester
  • HY-140282
    DBCO-PEG1-amine 2364591-79-5
    DBCO-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG1-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG1-amine
  • HY-140236
    t-Boc-Amido-PEG23-Amine 3068905-02-9 99.94%
    t-Boc-Amido-PEG23-Amine (Boc-NH-PEG23-NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Amido-PEG23-Amine
  • HY-133006
    Fluorescein-PEG5-acid 2183440-40-4
    Fluorescein-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Fluorescein-PEG5-acid
  • HY-130860
    Mal-NH-PEG2-CH2CH2COOPFP ester 1347750-81-5
    Mal-NH-PEG2-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-NH-PEG2-CH2CH2COOPFP ester
PROTAC Linkers Isoform Comparison

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